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EspañolDatos del Documento
| Título: Gestational Age, Perinatal Characteristics, and Autism Spectrum Disorder: A Birth Cohort Study | |
| Enlace: https://doi.org/10.1016/j.jpeds.2020.01.022 | |
| Autores: Brumbaugh, Jane E. ; Weaver , Amy L.; Myers, Scott M.; Voigt, Robert G.; Katusic, Slavica K.; | |
| Tipo de documento: Articulo de revista | |
| Idioma: Inglés | |
| Resumen: Objective To determine how gestational age relates to research-identified autism spectrum disorder (ASD-R) in the context of perinatal risk factors. Study design This is a population-based cohort study using the 1994-2000 Olmsted County Birth Cohort. Children included were born and remained in Olmsted County after age 3 years. ASD-R status was determined from signs and symptoms abstracted from medical and educational records. Cox proportional hazards models were fit to identify associations between perinatal characteristics and ASD-R. Results The incidence of preterm birth (<37 weeks' gestation) was 8.6% among 7876 children. The cumulative incidence of ASD-R was 3.8% (95% CI 3.3-4.2) at 21 years of age. Compared with children born at full term, the risk of ASD-R appeared to be increased for children born preterm with unadjusted hazard ratios (HRs) of 2.62 (95% CI 0.65-10.57), 1.68 (95% CI 0.54-5.29), and 1.60 (95% CI 1.06-2.40) for children born extremely preterm, very preterm, and moderate-to-late preterm, respectively. In a multivariable model adjusted for perinatal characteristics, the associations were attenuated with adjusted HRs of 1.75 (95% CI 0.41-7.40), 1.24 (95% CI 0.38-4.01), and 1.42 (95% CI 0.93-2.15), for children born extremely preterm, very preterm, and moderate-to-late preterm, respectively. Among children with maternal history available (N = 6851), maternal psychiatric disorder was associated with ASD-R (adjusted HR 1.73, 95% CI 1.24-2.42). Conclusions The increased risk of ASD-R among children born preterm relative to children born full term was attenuated by infant and maternal characteristics. |
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| Descriptores: preterm; late term; post-term; population-based; perinatal; psychiatric; prematuro tardío; | |
| Soporte: --No definido-- | |
| Ilustraciones: Sí | |
| Tipo documento: Revista | |
| Nombre revista: The Journal of Pediatrics | |
| ISSN: 0022-3476 | |
| Periodicidad: Mensual | |
| Volumen: 220 | |
| Número: | |
| Páginas: 175-183.e8 | |
| Año: 2020 |
Afiliada a WAIMHWorld Association
for Infant Mental Health
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