Resumen:This article examines whether children’s anger regulation mediates the relation of cancer-related parental posttraumatic stress symptoms (PTSS) to the psychological adjustment of children with cancer. Children with cancer, and their parents (N D 199; 52.3% boys), completed measures of parental PTSS, child anger regulation, and child adjustment. Parental cancer-related PTSS was significantly associated with child adjustment and anger regulation. Children’s anger regulation mediated the relation between parental PTSS and child behavioral and emotional difficulties. This suggests anger regulation as a possible target for intervention.