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EspañolDatos del Documento
| Título: Neuroleptic Malignant Syndrome in Children and Adolescent | |
| Enlace: https://doi.org/10.1097/00004583-199902000-00018 | |
| Autores: Silva, Raúl R.; Muñoz, Dinohra M. ; Alpert, Murray; Perlmutter, Ilisse R.; Díaz, José; | |
| Tipo de documento: Articulo de revista | |
| Idioma: Inglés | |
| Resumen:Objective:
Neuroleptic malignant syndrome (NMS) is a serious iatrogenic condition. This report reviews the world literature to characterize the syndrome and evaluate factors that promote early detection and effective intervention. Method: The review identified 77 NMS cases (49 males, 27 females, 1 gender unknown); ages ranged from 0.9 to 18 years (mean 14.8 ± 3.96). Univariate and multiple regression analyses were applied to 38 variables to identify early signs of the disorder, to identify correlates of outcome, and to evaluate treatments. Results: The duration of NMS spanned from 1 to 119 days. Nine percent of patients died and 20% resolved with serious sequelae. Patients receiving low-potency neuroleptics had a poorer outcome (p = .01). Fever was related to longer duration of illness (p = .03). Anticholinergics and bromocriptine were effective and without fatalities, but dantrolene was not useful in this sample of children and adolescents. Conclusions: Early detection and appropriate interventions appear important in moderating the course and outcome of NMS |
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| Descriptores: neuroleptic malignant syndrome; treatment; prognosis; adolescentes; niños; children; neurolépticos; | |
| Soporte: Digital | |
| Ilustraciones: Sí | |
| Tipo documento: Revista | |
| Nombre revista: Journal of the American Academy of Child and Adolescent Psychiatry | |
| ISSN: ISSN: 0890-8567 | |
| Periodicidad: | |
| Volumen: 38 | |
| Número: 2 | |
| Páginas: 187-194 | |
| Año: 1999 |
Afiliada a WAIMHWorld Association
for Infant Mental Health
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